Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk.

@article{Katsu2002NovelSP,
  title={Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk.},
  author={Rieko Katsu and Hiroshi Onogi and Kazuhiro Wada and Yasushi Kawaguchi and Masatoshi Hagiwara},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 46},
  pages={44220-8}
}
We identified a novel serine/arginine (SR)-rich-related protein as a binding partner of Clk4 mutant lacking kinase activity (Clk4 K189R) in the two-hybrid screen and designated it Clasp (Clk4-associating SR-related protein). Northern blot analysis revealed that Clasp mRNA was highly expressed in brain, and in situ hybridization of a mouse brain sagittal section hybridized with antisense probes revealed that both Clasp and Clk4 mRNAs were expressed in the hippocampus, the cerebellum, and the… CONTINUE READING

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