Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.

@article{Kuroyanagi1998NovelSK,
  title={Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.},
  author={N Kuroyanagi and Hiroshi Onogi and Takashi Wakabayashi and Masatoshi Hagiwara},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={242 2},
  pages={357-64}
}
SR-protein-specific kinase 1 (SRPK1) is first identified as a specific kinase for SR splicing factors. By RT-PCR of a conserved kinase domain, novel SR-protein-specific kinase clones were isolated from mouse brain. The cloned cDNAs encode a 106 kDa protein (648 amino acids, 92% identical to human SRPK1) and a 120 kDa protein (681 amino acids, 58% identical to human SRPK1). Therefore, they were designated mSRPK1 and mSRPK2, respectively. Northern blotting revealed the ubiquitous expression of… CONTINUE READING
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