• Corpus ID: 248575191

Novel Rp-Hplc-Pda Method for the Simultaneous Estimation of Metoprolol Succinate and Chlorthalidone in Bulk and Pharmaceutical Dosage Forms

@inproceedings{Jyothi2014NovelRM,
  title={Novel Rp-Hplc-Pda Method for the Simultaneous Estimation of Metoprolol Succinate and Chlorthalidone in Bulk and Pharmaceutical Dosage Forms},
  author={Aenugu Jyothi and Syed. Sadath Ali and Buchi N. Nalluri and Aziz Unnisa},
  year={2014}
}
The main objective of the study was to develop and validate a simple, precise, economical LC-MS compatible analytical method for the simultaneous estimation of Metoprolol succinate (MET) and Chlorthalidone (CT) by RP-HPLC-PDA. The method was carried out on Inertsil ODS column using mixture of 10mM ammonium acetate: acetonitrile in the ratio of 70:30%v/v as mobile phase. The flow rate was 1mL/min with PDA detection at 220nm. The retention times of MET and CT were 5.6min and 7.5min respectively… 
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