Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases

  title={Novel Resveratrol-Based Substrates
for Human Hepatic,
Renal, and Intestinal UDP-Glucuronosyltransferases},
  author={Aleksandra K. Greer and Nikhil Reddy Madadi and Stacie M. Bratton and Sarah D. Eddy and Zofia Mazerska and Howard P. Hendrickson and Peter A. Crooks and Anna Radomińska-Pandya},
  booktitle={Chemical research in toxicology},
Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs which would be glucuronidated at a lower rate than tRes itself. In… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications referenced by this paper.
Showing 1-10 of 23 references

Unusual glucuronides.

Drug metabolism and disposition: the biological fate of chemicals • 2012

Styrene - acid derivative and use in manufacturing blood - vessel targeted - agent drugs

Z. Yong, X. Xu
PCT Int . Appl . WO • 2009

Styrene-acid derivative and use

Z. Yong, X. Xu

Similar Papers

Loading similar papers…