Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases

@inproceedings{Greer2014NovelRS,
  title={Novel Resveratrol-Based Substrates
for Human Hepatic,
Renal, and Intestinal UDP-Glucuronosyltransferases},
  author={Aleksandra K. Greer and Nikhil Reddy Madadi and Stacie M. Bratton and Sarah D. Eddy and Zofia Mazerska and Howard P. Hendrickson and Peter A. Crooks and Anna Radomińska-Pandya},
  booktitle={Chemical research in toxicology},
  year={2014}
}
Trans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anticarcinogenic, and antiaging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs which would be glucuronidated at a lower rate than tRes itself. In… CONTINUE READING
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