Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).

@article{Yue2014NovelRP,
  title={Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3).},
  author={Michael M. Yue and Kaosheng Lv and S. C. Meredith and Jennifer L. Martindale and M. J. Franc{\'e}s Gorospe and Lucia A Schuger},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 49},
  pages={
          33971-83
        }
}
P311, a conserved 8-kDa intracellular protein expressed in brain, smooth muscle, regenerating tissues, and malignant glioblastomas, represents the first documented stimulator of TGF-β1-3 translation in vitro and in vivo. Here we initiated efforts to define the mechanism underlying P311 function. PONDR® (Predictor Of Naturally Disordered Regions) analysis suggested and CD confirmed that P311 is an intrinsically disordered protein, therefore requiring an interacting partner to acquire tertiary… CONTINUE READING
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