Novel RIPK3 inhibitors discovered through a structure-based approach exert post-ischemic neuroprotection

Abstract

Necroptosis or programmed necrosis is evident in various neurological disorders such as ischemic stroke. Receptor interacting serine/threonine protein kinase 3 (RIPK3) is one of the crucial targets of necroptosis and inhibition of this protein exerts neuroprotection. However, knowledge regarding the three-dimensional structure and binding site information… (More)
DOI: 10.1007/s11030-016-9663-1

Topics

9 Figures and Tables