Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice

@article{Lu2012NovelQM,
  title={Novel Quinazolinone MJ-29 Triggers Endoplasmic Reticulum Stress and Intrinsic Apoptosis in Murine Leukemia WEHI-3 Cells and Inhibits Leukemic Mice},
  author={Chi-Cheng Lu and J. Yang and Jo-Hua Chiang and M. Hour and Kuei-Li Lin and Jen-Jyh Lin and Wen-Wen Huang and M. Tsuzuki and T. Lee and J. Chung},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
The present study was to explore the biological responses of the newly compound, MJ-29 in murine myelomonocytic leukemia WEHI-3 cells in vitro and in vivo fates. We focused on the in vitro effects of MJ-29 on ER stress and mitochondria-dependent apoptotic death in WEHI-3 cells, and to hypothesize that MJ-29 might fully impair the orthotopic leukemic mice. Our results indicated that a concentration-dependent decrease of cell viability was shown in MJ-29-treated cells. DNA content was examined… Expand
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