Novel Protamine-Based Polyelectrolyte Carrier Enhances Low-Dose rhBMP-2 in Posterolateral Spinal Fusion.

Abstract

STUDY DESIGN A rodent posterolateral spinal fusion model. OBJECTIVE This study evaluated a protamine-based polyelectrolyte complex (PEC) developed to use heparin in enhancing the biological activity of low-dose recombinant human bone morphogenetic protein-2 (rhBMP-2) in spinal fusion. SUMMARY OF BACKGROUND DATA rhBMP-2 is commonly regarded as the most… (More)
DOI: 10.1097/BRS.0000000000000841

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