Novel Polyester-Polysaccharide Nanoparticles

  title={Novel Polyester-Polysaccharide Nanoparticles},
  author={Caroline Lemarchand and Patrick Couvreur and Madeleine Besnard and Dominique Costantini and Ruxandra Gref},
  journal={Pharmaceutical Research},
AbstractPurpose. The aim of the present study was to develop a new type of core-shell nanoparticles from a family of novel amphiphilic copolymers, based on dextran (DEX) grafted with poly(ε–caprolactone) (PCL) side chains (PCL-DEX). Methods. A family of PCL-DEX copolymers was synthesized in which both the molecular weight and the proportion by weight of DEX in the copolymer were varied. The nanoparticles were prepared by a technique derived from emulsion-solvent evaporation, during which… 
Physico-chemical characterization of polysaccharide-coated nanoparticles.
Physicochemical characterization of self-assembled poly(∈-caprolactone) grafted dextran nanoparticles
Amphiphilic graft copolymer composed of poly(∈-caprolactone) and dextran was synthesized by ring opening polymerization of ∈-caprolactone initiated through the hydroxyl end of dextran in the presence
Influence of polysaccharide coating on the interactions of nanoparticles with biological systems.
Nanoparticles made from novel starch derivatives for transdermal drug delivery.


Protein encapsulation within polyethylene glycol-coated nanospheres. I. Physicochemical characterization.
It was shown that the P EG "brush" at the nanosphere surface drastically reduces HSA adsorption on the PEG-PLA nanospheres compared to the PLA ones.
Polysaccharides Grafted with Polyesters: Novel Amphiphilic Copolymers for Biomedical Applications
Nanoparticles of less than 200 nm, with potential interest for controlled release of bioactive compounds, were successfully prepared by using new amphiphilic copolymers with various hydrophilic−lipophilic balance.
Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.
Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto deXTran and thus leading to the formation of entanglements between the hydrophobically modified dextrans parts and the PLA matrix.
Pegylated Nanoparticles from a Novel Methoxypolyethylene Glycol Cyanoacrylate-Hexadecyl Cyanoacrylate Amphiphilic Copolymer
A complete physico-chemical characterization, including surface chemical analysis, allowed to confirm the formation of PEG-coated nanoparticles, and the PEGylation of the cyanoacrylate polymer showed reduced cytotoxicity towards mouse peritoneal macrophages.
Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system.
Nanoparticles prepared from methoxy poly(ethylene glycol)poly(d,l-lactic acid) block copolymers or blends of Me.PEG-PLA and PLA were shown to be more slowly captured by cultured THP-1 monocytes than F68-coated PLA nanoparticles, in a PEG chain-length-dependent manner.
Design of folic acid-conjugated nanoparticles for drug targeting.
Folate-linked nanoparticles represent a potential new drug carrier for tumor cell-selective targeting in PEG-coated biodegradable nanoparticles coupled to folic acid to target the folate-binding protein.
Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS.
Preparation of poly(lactic acid)-grafted amylose through the trimethylsilyl protection method and its biodegradation
Biodegradable poly(lactic acid)-grafted amylose was synthesized using a trimethylsilyl (TMS) protection method. Tetrahydrofuran soluble, mostly trimethylsilyl protected amylose was prepared and