Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming

Abstract

A series of hybrid compounds was designed to target histone deacetylases and ds-/G-quadruplex DNAs by merging structural features deriving from Scriptaid and compound 1. Compound 6 binds different DNA arrangements, inhibits HDACs both in vitro and in cells, and is able to induce a reduction of cell proliferation. Moreover, compound 6 displays cell phenotype… (More)
DOI: 10.1021/acsmedchemlett.7b00289

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Cite this paper

@inproceedings{Pasini2017NovelPD, title={Novel Polyamine–Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming}, author={Alice Pasini and Chiara Marchetti and Claudia Sissi and Marilisa Cortesi and Emanuele Giordano and Anna Minarini and Andrea Milelli}, booktitle={ACS medicinal chemistry letters}, year={2017} }