Novel PLA modification of organic microcontainers based on ring opening polymerization: synthesis, characterization, biocompatibility and drug loading/release properties.

@article{Efthimiadou2012NovelPM,
  title={Novel PLA modification of organic microcontainers based on ring opening polymerization: synthesis, characterization, biocompatibility and drug loading/release properties.},
  author={Eleni K. Efthimiadou and L-A Tziveleka and Panayiotis Bilalis and G. I. Kordas},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={428 1-2},
  pages={134-42}
}
In the current study, poly lactic acid (PLA) modified hollow crosslinked poly(hydroxyethyl methacrylate) (PHEMA) microspheres have been prepared, in order to obtain a stimulus-responsive, biocompatible carrier with sustained drug release properties. The synthetical process consisted of the preparation of poly(methacrylic acid)@poly(hydroxyethyl methacrylate-co-N,N'-methylene bis(acrylamide)) microspheres by a two stage distillation-precipitation polymerization technique using 2,2… CONTINUE READING