Novel Organic Cation Transporter 2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells

  title={Novel Organic Cation Transporter 2-Mediated Carnitine Uptake in Placental Choriocarcinoma (BeWo) Cells},
  author={Erik Rytting and Kenneth L. Audus},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={192 - 198}
  • E. Rytting, K. Audus
  • Published 1 January 2005
  • Biology
  • Journal of Pharmacology and Experimental Therapeutics
The placental transport of carnitine is significant because the fetus cannot supply itself with adequate amounts of this nutrient. Carnitine deficiencies in infants can lead to symptoms ranging from muscle weakness to sudden infant death. Objectives of this study include the characterization of novel organic cation transporter 2 (OCTN2) function in the BeWo cell line and the inhibition of placental carnitine uptake by amphetamine derivatives. BeWo cells were seeded in 12- or 24-well tissue… 

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