Novel Opioid Peptide Amidorphin: Characterization and Distribution of Amidorphin‐Like Immunoreactivity in Bovine, Ovine, and Porcine Brain, Pituitary, and Adrenal Medulla

@article{Liebisch1985NovelOP,
  title={Novel Opioid Peptide Amidorphin: Characterization and Distribution of Amidorphin‐Like Immunoreactivity in Bovine, Ovine, and Porcine Brain, Pituitary, and Adrenal Medulla},
  author={D. C. Liebisch and Bernd R. Seizinger and Gregory J Michael and Albert Herz},
  journal={Journal of Neurochemistry},
  year={1985},
  volume={45}
}
Abstract: We have recently isolated from bovine adrenal medulla a novel C‐terminally amidated opioid peptide, amidorphin, which derives from proenkephalin A. Amidorphin revealed a widespread distribution in bovine, ovine, and porcine tissue. Particularly high concentrations of amidorphin immunoreactivity were detected in adrenal medulla, posterior pituitary, and striatum, similar to the major gene products of proenkephalin A. In the adrenal medulla of each species. authentic amidorphin was the… 
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Very high concentrations of amidorphin were detected in bovine adrenal medulla and in a further endocrinological system, the hypothalamic–neurohypophyseal axis, and may be considered to be a major gene product of the opioid peptide precursor proenkephalin A in these endocrine tissues.
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