Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect.

@article{Shen2011NovelNO,
  title={Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect.},
  author={Jinqiu Shen and Li Gan and Chunliu Zhu and Xinxin Zhang and Yang Xiao Dong and Min Jiang and Jiabi Zhu and Yong Gan},
  journal={International journal of pharmaceutics},
  year={2011},
  volume={412 1-2},
  pages={
          115-22
        }
}
The aim of this study was to design and formulate a novel low-irritant NSAIDs ophthalmic emulsion of flurbiprofen axetil (FBA), the prodrug of flurbiprofen (FB). FBA ophthalmic emulsion (FBA-EM) was prepared by high-pressure homogenization with caster oil as oil phase and tween 80 as emulsifying agent. Results from the stability evaluation suggested the protect effect of oil droplets on the stability of FBA. Compared with FBA-oil solution, the AUC(0→10h) of FB in aqueous humor administered in… CONTINUE READING
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