Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

@article{Rondeau1992NovelND,
  title={Novel NADPH-binding domain revealed by the crystal structure of aldose reductase},
  author={J. Rondeau and F. T{\^e}te-Favier and A. Podjarny and J. Reymann and P. Barth and J. Biellmann and D. Moras},
  journal={Nature},
  year={1992},
  volume={355},
  pages={469-472}
}
  • J. Rondeau, F. Tête-Favier, +4 authors D. Moras
  • Published 1992
  • Chemistry, Medicine
  • Nature
  • ALDOSE reductase is the first enzyme in the polyol pathway and catalyses the NADPH-dependent reduction of D-glucose to D-sorbitol. Under normal physiological conditions aldose reductase participates in osmoregulation1, but under hyperglycaemic conditions it contributes to the onset and development of severe complications in diabetes2. Here we present the crystal structure of pig lens aldose reductase refined to an R-factor of 0.232 at 2.5-Å resolution. It exhibits a single domain folded in an… CONTINUE READING
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