Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery.

@article{Jacobson2003NovelNO,
  title={Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery.},
  author={Gary M Jacobson and Hector M Dourron and Jianhua Liu and Oscar A. Carretero and Dr.A.Ramamohan Reddy and Tanja Andrzejewski and Patrick J Pagano},
  journal={Circulation research},
  year={2003},
  volume={92 6},
  pages={
          637-43
        }
}
Neointimal proliferation occurring after vascular or endovascular procedures is a major complication leading to end-organ or limb ischemia. In experimental models, balloon injury has been shown to induce NAD(P)H oxidase to produce vascular superoxide anion (O2*-) production, which has been implicated in cell proliferation, but a direct link is still unclear. We postulated that inhibition of arterial NAD(P)H oxidase, resulting in decreased O2*-, would lessen the neointimal hyperplasia caused by… CONTINUE READING

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