Novel Mycosin Protease MycP1 Inhibitors Identified by Virtual Screening and 4D Fingerprints

Abstract

The rise of drug-resistant Mycobacterium tuberculosis lends urgency to the need for new drugs for the treatment of tuberculosis (TB). The identification of a serine protease, mycosin protease-1 (MycP₁), as the crucial agent in hydrolyzing the virulence factor, ESX-secretion-associated protein B (EspB), potentially opens the door to new tuberculosis… (More)
DOI: 10.1021/ci500025r

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