Novel Mutations of Neurofibromatosis Type 1 Gene in Small Cell Lung Cancers


Purpose: Mutations in the GTPase-activating protein-related domain (GRD) of the von Recklinghausen neurofibromatosis type 1 (NF1) gene have been reported in several tumors that were not previously associated with NF1. We analyzed 37 cases of lung cancer, including 9 cases of small cell carcinoma, to detect mutations in this domain. Methods: DNA was… (More)
DOI: 10.1007/s005950300074


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