Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis

@article{Hoffmann2005NovelMM,
  title={Novel Mouse Model of Chronic Pseudomonas aeruginosa Lung Infection Mimicking Cystic Fibrosis},
  author={Nadine Hoffmann and T. B. Rasmussen and P. Jensen and C. Stub and M. Hentzer and S. Molin and O. Ciofu and M. Givskov and H. Johansen and N. H{\o}iby},
  journal={Infection and Immunity},
  year={2005},
  volume={73},
  pages={2504 - 2514}
}
ABSTRACT Pseudomonas aeruginosa causes a chronic infection in the lungs of cystic fibrosis (CF) patients by establishing an alginate-containing biofilm. The infection has been studied in several animal models; however, most of the models required artificial embedding of the bacteria. We present here a new pulmonary mouse model without artificial embedding. The model is based on a stable mucoid CF sputum isolate (NH57388A) with hyperproduction of alginate due to a deletion in mucA and functional… Expand
Novel experimental Pseudomonas aeruginosa lung infection model mimicking long-term host–pathogen interactions in cystic fibrosis
Murine models of acute and chronic lung infection with cystic fibrosis pathogens.
  • A. Bragonzi
  • Biology, Medicine
  • International journal of medical microbiology : IJMM
  • 2010
Pseudomonas aeruginosa biofilms in cystic fibrosis.
Interleukin-17 Is Required for Control of Chronic Lung Infection Caused by Pseudomonas aeruginosa
Role of quorum sensing by Pseudomonas aeruginosa in microbial keratitis and cystic fibrosis.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection
Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres
Chronic Pseudomonas aeruginosa lung infection in normal and athymic rats
...
1
2
3
4
5
...