Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6.

@article{Xu2017NovelMI,
  title={Novel Molecular Insights into the Catalytic Mechanism of Marine Bacterial Alginate Lyase AlyGC from Polysaccharide Lyase Family 6.},
  author={Fei Xu and Fang Dong and Peng Wang and Hai-Yan Cao and Chun-yang Li and Ping-Yi Li and Xiu-Hua Pang and Yu-Zhong Zhang and Xiu-lan Chen},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 11},
  pages={4457-4468}
}
Alginate lyases that degrade alginate via a β-elimination reaction fall into seven polysaccharide lyase (PL) families. Although the structures and catalytic mechanisms of alginate lyases in the other PL families have been clarified, those in family PL6 have yet to be revealed. Here, the crystal structure of AlyGC, a PL6 alginate lyase from marine bacterium Glaciecola chathamensis S18K6T, was solved, and its catalytic mechanism was illustrated. AlyGC is a homodimeric enzyme and adopts a… CONTINUE READING
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