Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

@inproceedings{Howell2017NovelMO,
  title={Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing},
  author={Kristen Howell and Chun R.U. Chien and Rebecca L. Bell and Damien M. Laudier and Sara F. Tufa and Douglas R. Keene and Nelly Andarawis-Puri and Alice H Huang},
  booktitle={Scientific reports},
  year={2017}
}
To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using neonatal mice and show that neonates heal via formation of a 'neo-tendon' that differentiates along the tendon specific lineage with functional restoration of gait and mechanical properties. In contrast, adults heal via fibrovascular scar, aberrant differentiation toward cartilage and bone, with persistently impaired function. Lineage tracing… CONTINUE READING
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