Novel Mode of Ligand Recognition by the Erbin PDZ Domain*

  title={Novel Mode of Ligand Recognition by the Erbin PDZ Domain*},
  author={Gabriel Birrane and Ju Young Chung and John A. A. Ladias},
  journal={The Journal of Biological Chemistry},
  pages={1399 - 1402}
Erbin contains a class I PDZ domain that binds to the C-terminal region of the receptor tyrosine kinase ErbB2, a class II ligand. The crystal structure of the human Erbin PDZ bound to the peptide EYLGLDVPV corresponding to the C-terminal residues 1247–1255 of human ErbB2 has been determined at 1.25-Å resolution. The Erbin PDZ deviates from the canonical PDZ fold in that it contains a single α-helix. The isopropyl group of valine at position −2 of the ErbB2 peptide interacts with the Erbin… 

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