Novel Membrane-Bound eIF2α Kinase in the Flagellar Pocket of Trypanosoma brucei

@article{Moraes2007NovelME,
  title={Novel Membrane-Bound eIF2$\alpha$ Kinase in the Flagellar Pocket of Trypanosoma brucei},
  author={M. C. S. Moraes and T. C. L. Jesus and N. N. Hashimoto and Madhusudan Dey and K. Schwartz and V. S. Alves and C. C. Avila and J. Bangs and T. E. Dever and S. Schenkman and B. Castilho},
  journal={Eukaryotic Cell},
  year={2007},
  volume={6},
  pages={1979 - 1991}
}
ABSTRACT Translational control mediated by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2α) is central to stress-induced programs of gene expression. Trypanosomatids, important human pathogens, display differentiation processes elicited by contact with the distinct physiological milieu found in their insect vectors and mammalian hosts, likely representing stress situations. Trypanosoma brucei, the agent of African trypanosomiasis, encodes three potential eIF2… Expand
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