Novel MITF targets identified using a two‐step DNA microarray strategy

  title={Novel MITF targets identified using a two‐step DNA microarray strategy},
  author={K. Hoek and Natalie C Schlegel and O. Eichhoff and D. Widmer and Christian Praetorius and Steingrimur O Einarsson and S. Valgeirsd{\'o}ttir and Kristin Bergsteinsdottir and Alexander Schepsky and R. Dummer and E. Steingr{\'i}msson},
  journal={Pigment Cell & Melanoma Research},
  • K. Hoek, Natalie C Schlegel, +8 authors E. Steingrímsson
  • Published 2008
  • Biology, Medicine
  • Pigment Cell & Melanoma Research
  • Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent advances in our understanding of the disease at the molecular level have indicated that it shares many characteristics with developmental precursors to melanocytes, the mature pigment‐producing cells of the skin and hair follicles. The development of melanocytes absolutely depends on the action of the microphthalmia‐associated transcription factor (MITF). MITF has been shown to regulate a broad variety of genes… CONTINUE READING
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