Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model

@inproceedings{Rak2014NovelLI,
  title={Novel LIMK2 Inhibitor Blocks Panc-1 Tumor Growth in a mouse xenograft model},
  author={Roni Rak and Roni Haklai and Galit Elad-Tzfadia and Haim J. Wolfson and Shmuel Carmeli and Yoel Kloog},
  booktitle={Oncoscience},
  year={2014}
}
LIM kinases (LIMKs) are important cell cytoskeleton regulators that play a prominent role in cancer manifestation and neuronal diseases. The LIMK family consists of two homologues, LIMK1 and LIMK2, which differ from one another in expression profile, intercellular localization, and function. The main substrate of LIMK is cofilin, a member of the actin-depolymerizing factor (ADF) protein family. When phosphorylated by LIMK, cofilin is inactive. LIMKs play a contributory role in several… CONTINUE READING

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