Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.


Long QT syndrome (LQTS) is an inherited disease involving mutations in the genes encoding a number of cardiac ion channels and a membrane adaptor protein. Among the genes that are responsible for LQTS, KCNE1 and KCNE2 are members of the KCNE family of genes, and function as ancillary subunits of Kv channels. The third KCNE gene, KCNE3, is expressed in… (More)
DOI: 10.1002/humu.20834


5 Figures and Tables