Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.

@article{Perkins1988NovelJA,
  title={Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.},
  author={Katherine K. Perkins and G. Dailey and Robert Tjian},
  journal={The EMBO journal},
  year={1988},
  volume={7 13},
  pages={4265-73}
}
A homolog of mammalian enhancer binding factor AP-1 was detected in Drosophila and was purified from embryo nuclear extracts by sequence-specific DNA affinity chromatography. The purified fraction, dAP-1, displays the sequence specificity as well as transcriptional activation properties of mammalian AP-1 and consists of two major proteins of mol. wts 40 and 70 kd. Antibody cross-reactivity experiments suggest that these proteins are Drosophila homologs of proto-oncogene products, Jun and Fos… CONTINUE READING

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