Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model

@article{Bin2014NovelIE,
  title={Novel Inhibitory Effect of N-(2-Hydroxycyclohexyl)valiolamine on Melanin Production in a Human Skin Model},
  author={Bum-Ho Bin and Yung Hyup Joo and Ai-Young Lee and Song Seok Shin and Eun-Gyung Cho and Tae Ryong Lee},
  journal={International Journal of Molecular Sciences},
  year={2014},
  volume={15},
  pages={12188 - 12195}
}
Hyper-pigmentation causes skin darkness and medical disorders, such as post-inflammatory melanoderma and melasma. Therefore, the development of anti-melanogenic agents is important for treating these conditions and for cosmetic production. In our previous paper, we demonstrated that the anti-diabetic drug voglibose, a valiolamine derivative, is a potent anti-melanogenic agent. In addition, we proposed an alternative screening strategy to identify valiolamine derivatives with high skin… 
The synergistic effect of maltose enhances the anti-melanogenic activity of acarbose
TLDR
The results suggest that the co-treatment of anti-hyperglycemic agents with hydrolysable sugars may be a useful tool for reducing glucosidase-associated melanogenesis as a potent sugar-based anti-melanogenic regimen.
The Development of Sugar-Based Anti-Melanogenic Agents
TLDR
Evidence of the utility of sugar-based anti-melanogenic agents in managing skin darkness and curing pigmentary disorders is provided and a future direction for the development of physiologically favorable anti-Melanogenicagents is suggested.
Role of Vitamin C in Skin Diseases
TLDR
The effects of vitamin C on four skin diseases (porphyria cutanea tarda, atopic dermatitis, malignant melanoma, and herpes zoster and postherpetic neuralgia) are summarized and the potential of vitaminC as a therapeutic strategy to treat these diseases is highlighted, emphasizing the clinical application of vitamin D as an adjuvant for drugs or physical therapy in other skin diseases.
Current Methods for the Discovery of New Active Ingredients from Natural Products for Cosmeceutical Applications.
TLDR
In this review, in vitro (enzymatic and cellular) and in vivo tests employed to evaluate the potential of new cosmeceutical active ingredients are discussed, and new trends that are being explored by the cosmecutical industry are described.
Fibronectin-Containing Extracellular Vesicles Protect Melanocytes against Ultraviolet Radiation-Induced Cytotoxicity.
TLDR
These findings suggest that melanocytes secrete fibronectin-containing extracellular vesicles to increase their survival after UVB radiation, and provide important insight into how constantly stimulated melanocytes can be maintained in pathological conditions such as melasma.

References

SHOWING 1-10 OF 16 REFERENCES
Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis
TLDR
Voglibose was the most efficient antimelanogenic agent among the widely used antihyperglycaemic agents, and an alternative strategy for screening compounds from valiolamine derivatives that show high inhibitory activity towards human intracellular α‐glucosidases and high cell permeability is proposed.
Synthesis and alpha-D-glucosidase inhibitory activity of N-substituted valiolamine derivatives as potential oral antidiabetic agents.
Various kinds of N-substituted valiolamine derivatives, including compounds 23a, 24a, and 34a, which are structurally analogous to the key pseudodisaccharides (25a and 26a) of naturally occurring
Melanin pigmentation in mammalian skin and its hormonal regulation.
TLDR
Melanogenesis is a highly structured system, active since early embryogenesis and capable of superselective functional regulation that may reach down to the cellular level represented by single melanocytes, and its significance extends beyond the mere assignment of a color trait.
The role of melanin in the induction of oxidative DNA base damage by ultraviolet A irradiation of DNA or melanoma cells.
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet radiation than light-colored human skin. The extent to which tanning protects skin from harmful effects
Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color.
TLDR
The treatment of postinflammatory hyperpigmentation should be started early to help hasten its resolution and begins with management of the initial inflammatory condition.
L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions
There is evidence that L‐tyrosine and L‐dihydroxyphenylalanine (L‐DOPA), besides serving as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not only as inducers
Oral antidiabetic agents: current role in type 2 diabetes mellitus.
TLDR
Concern about cardiovascular safety of sulphonylureas has largely dissipated with generally reassuring results from clinical trials, including the UKPDS, and the insulin-sensitising thiazolidinedione class of antidiabetic agents has potentially advantageous effects on multiple components of the metabolic syndrome.
Comparison of Skin Color with Melanin Content1
TLDR
In a further effort to analyze the nature of the differences between various skin colors, it was considered desirable to make a histologic study of the skin of different individuals from biopsy specimens.
Comparison of skin color with melanin content.
TLDR
In a further effort to analyze the nature of the differences between various skin colors, it was considered desirable to make a histologic study of the skin of different individuals from biopsy specimens.
Postinflammatory hyperpigmentation: a common but troubling condition
Postinflammatory hyperpigmentation (PIH) is one of the most common causes of an altered normal skin color. 1 It represents the sequelae of various cutaneous disorders as well as therapeutic
...
1
2
...