Novel Inhibitors of Leukotrienes Synthesis in a Treatment of Inflammatory Pain

@inproceedings{CegielskaPerun2017NovelIO,
  title={Novel Inhibitors of Leukotrienes Synthesis in a Treatment of Inflammatory Pain},
  author={Krystyna Cegielska-Perun and Ewa Marczuk and MAGDALENA BUJALSKA-ZADRO\ONY},
  year={2017}
}
A search of new analgesic and anti-inflammatory agents is still ongoing. It is well known that an activation of the leukotriene (LT) synthesis is involved in pain signaling. LTs belong to a class of potent proinflammatory mediators that are biosynthesized from arachidonic acid (AA) inter alia by 5-lipoxygenase (5LOX) enzyme in association with 5-LOX-activating protein (FLAP). Therefore, the main goal of this article review was to present recent advances on new compounds influencing the LOX… CONTINUE READING