Novel IgE peptide-based vaccine prevents the increase of IgE and down-regulates elevated IgE in rodents.

Abstract

BACKGROUND Immunotherapy with anti-IgE antibodies for treatment of allergy is promising but a short half-life and extremely high cost limit its application. OBJECTIVE We sought to develop IgE vaccines that induce longer-lasting auto-antibodies to neutralize self-IgE as an alternative therapy. METHODS The vaccine was made by conjugating three synthetic… (More)

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