Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.

  title={Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.},
  author={H. Hirai and M. Roussel and J. Kato and R. Ashmun and C. Sherr},
  journal={Molecular and cellular biology},
  pages={2672 - 2681}
  • H. Hirai, M. Roussel, +2 authors C. Sherr
  • Published 1995
  • Biology, Medicine
  • Molecular and cellular biology
  • Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two novel members of the mouse INK4 gene family, p19 and p18, that specifically inhibit the kinase activities of CDK4 and CDK6, but do not affect those of cyclin E-CDK2, cyclin A-CDK2, or cyclin B-CDC2, were isolated. Like the previously described human INK4 polypeptides, p16INK4a/MTS1 and p15INK4b/MTS2, mouse p19 and p18 are primarily composed of tandemly repeated ankyrin… CONTINUE READING
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