Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.

@article{Hirai1995NovelIP,
  title={Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.},
  author={H. Hirai and M. Roussel and J. Kato and R. Ashmun and C. Sherr},
  journal={Molecular and cellular biology},
  year={1995},
  volume={15},
  pages={2672 - 2681}
}
  • H. Hirai, M. Roussel, +2 authors C. Sherr
  • Published 1995
  • Biology, Medicine
  • Molecular and cellular biology
  • Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two novel members of the mouse INK4 gene family, p19 and p18, that specifically inhibit the kinase activities of CDK4 and CDK6, but do not affect those of cyclin E-CDK2, cyclin A-CDK2, or cyclin B-CDC2, were isolated. Like the previously described human INK4 polypeptides, p16INK4a/MTS1 and p15INK4b/MTS2, mouse p19 and p18 are primarily composed of tandemly repeated ankyrin… CONTINUE READING
    668 Citations
    Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
    • 180
    • PDF
    Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
    • 218
    • Highly Influenced
    • PDF
    Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.
    • 336
    • PDF
    Cyclin E-CDK2 is a regulator of p27Kip1.
    • 955
    • PDF

    References

    SHOWING 1-10 OF 74 REFERENCES
    The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • 5,548
    p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • 2,059
    Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.
    • 212
    • PDF
    Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.
    • 1,191
    • PDF
    Identification of G1 kinase activity for cdk6, a novel cyclin D partner.
    • 800
    • PDF
    A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • 3,625
    • Highly Influential
    • PDF