Novel IL-12 family members shed light on the orchestration of Th1 responses.

@article{Brombacher2003NovelIF,
  title={Novel IL-12 family members shed light on the orchestration of Th1 responses.},
  author={Frank Brombacher and Robert A. Kastelein and Gottfried Alber},
  journal={Trends in immunology},
  year={2003},
  volume={24 4},
  pages={207-12}
}
Interleukin-12 (IL-12), which is composed of a p35 and a p40 subunit, is a proinflammatory natural-killer (NK) cell-stimulating, Th1-inducing and Th1-maintaining cytokine, which promotes cell-mediated immunity. On activation, heterodimeric IL-12 is found in small amounts, whereas free p40 is produced in excess. Besides IL-12, other p40-dependent molecules exist that orchestrate Th1 responses. Homodimeric p40 can act as an IL-12 antagonist by competing for its receptor. Recent data also reveal… CONTINUE READING

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