Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State

Abstract

Human embryonic stem cells (hESCs) undergo epigenetic changes in vitro which may compromise function, so an epigenetic pluripotency "signature" would be invaluable for line validation. We assessed Cytosine-phosphate-Guanine Island (CGI) methylation in hESCs by genomic DNA hybridisation to a CGI array, and saw substantial variation in CGI methylation between… (More)
DOI: 10.1371/journal.pone.0131102

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Cite this paper

@inproceedings{Pells2015NovelHE, title={Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State}, author={Steve C Pells and Eirini Koutsouraki and Sofia Morfopoulou and Sara Valencia-Cadavid and Simon R. Tomlinson and Ravi Kiran Reddy Kalathur and Matthias E. Futschik and P A De Sousa and Jason Glenn Knott}, booktitle={PloS one}, year={2015} }