Novel Heparan Sulfate-Binding Peptides for Blocking Herpesvirus Entry

@inproceedings{Dogra2015NovelHS,
  title={Novel Heparan Sulfate-Binding Peptides for Blocking Herpesvirus Entry},
  author={Pranay Dogra and Emily B Martin and Angela Williams and Raphael L. Richardson and James S. Foster and Nicole Hackenback and Stephen J. Kennel and Tim E. Sparer and Jonathan S Wall},
  booktitle={PloS one},
  year={2015}
}
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. Upon immune suppression, reactivation of latent HCMV or primary infection increases morbidity in cancer, transplantation, and late stage AIDS patients. Current treatments include nucleoside analogues, which have significant toxicities limiting their usefulness. In this study we screened a panel of synthetic heparin-binding peptides for their ability to prevent CMV infection in vitro. A peptide… CONTINUE READING
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