Novel Heparan Sulfate-Binding Peptides for Blocking Herpesvirus Entry

  title={Novel Heparan Sulfate-Binding Peptides for Blocking Herpesvirus Entry},
  author={Pranay Dogra and Emily B Martin and Angela Williams and Raphael L. Richardson and James S. Foster and Nicole Hackenback and Stephen J. Kennel and Tim E. Sparer and Jonathan S Wall},
  booktitle={PloS one},
Human cytomegalovirus (HCMV) infection can lead to congenital hearing loss and mental retardation. Upon immune suppression, reactivation of latent HCMV or primary infection increases morbidity in cancer, transplantation, and late stage AIDS patients. Current treatments include nucleoside analogues, which have significant toxicities limiting their usefulness. In this study we screened a panel of synthetic heparin-binding peptides for their ability to prevent CMV infection in vitro. A peptide… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 59 references

In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.

Proceedings of the National Academy of Sciences of the United States of America • 2011
View 6 Excerpts
Highly Influenced

Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry.

The Journal of clinical investigation • 2001
View 15 Excerpts
Highly Influenced

Basic statistics in cell biology.

Annual review of cell and developmental biology • 2014
View 1 Excerpt