Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway

@inproceedings{Bernard2014NovelHM,
  title={Novel HIV-1 MiRNAs Stimulate TNFα Release in Human Macrophages via TLR8 Signaling Pathway},
  author={Mark A. Bernard and Hui Zhao and Simon C. Yue and Asha Anandaiah and Henry Koziel and Souvenir D. Tachado},
  booktitle={PloS one},
  year={2014}
}
PURPOSE To determine whether HIV-1 produces microRNAs and elucidate whether these miRNAs can induce inflammatory response in macrophages (independent of the conventional miRNA function in RNA interference) leading to chronic immune activation. METHODS Using sensitive quantitative Real Time RT-PCR and sequencing, we detected novel HIV-derived miRNAs in the sera of HIV+ persons, and associated with exosomes. Release of TNFα by macrophages challenged with HIV miRNAs was measured by ELISA… CONTINUE READING
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