Novel HDL-directed pharmacotherapeutic strategies

  title={Novel HDL-directed pharmacotherapeutic strategies},
  author={Emil M Degoma and Daniel J. Rader},
  journal={Nature Reviews Cardiology},
The burden of atherothrombotic cardiovascular disease remains high despite currently available optimum medical therapy. To address this substantial residual risk, the development of novel therapies that attempt to harness the atheroprotective functions of HDL is a major goal. These functions include the critical role of HDL in reverse cholesterol transport, and its anti-inflammatory, antithrombotic, and antioxidant activities. Discoveries in the past decade have shed light on the complex… CONTINUE READING