Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner

@inproceedings{Nakamura2013NovelHM,
  title={Novel HCN2 Mutation Contributes to Febrile Seizures by Shifting the Channel's Kinetics in a Temperature-Dependent Manner},
  author={Yuki Nakamura and Xiuyu Shi and Tomohiro Numata and Yasuo Mori and Ryuji Inoue and Christoph Lossin and Tallie Z. Baram and Shinichi Hirose},
  booktitle={PloS one},
  year={2013}
}
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated currents, known as I h, are involved in the control of rhythmic activity in neuronal circuits and in determining neuronal properties including the resting membrane potential. Recent studies have shown that HCN channels play a role in seizure susceptibility and in absence and limbic epilepsy including temporal lobe epilepsy following long febrile seizures (FS). This study focused on the potential contributions of… CONTINUE READING
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