Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

@article{CastanoBetancourt2016NovelGV,
  title={Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis},
  author={M. Castano-Betancourt and Daniel S. Evans and Yolande F M Ramos and C. Boer and S. Metrustry and Youfang Liu and W. D. den Hollander and J. van Rooij and V. Kraus and M. Yau and B. Mitchell and K. Muir and A. Hofman and M. Doherty and S. Doherty and Weiya Zhang and R. Kraaij and F. Rivadeneira and E. Barrett-Connor and R. Maciewicz and N. Arden and R. Nelissen and M. Kloppenburg and J. Jordan and M. Nevitt and E. Slagboom and D. Hart and F. Lafeber and U. Styrkarsdottir and E. Zeggini and E. Evangelou and T. Spector and A. Uitterlinden and N. Lane and I. Meulenbelt and A. Valdes and J. V. van Meurs},
  journal={PLoS Genetics},
  year={2016},
  volume={12}
}
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different… Expand
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