Novel GABA responses from rod- driven retinal horizontal cells

  title={Novel GABA responses from rod- driven retinal horizontal cells},
  author={Haohua Qian and John E. Dowling},
γ-AMINOBUTYRIC acid (GABA) is the main inhibitory neurotransmitter in the central nervous system. Two classes of GABA receptors (GABAA and GABAB) have been identified. GABAA receptors are ligandgated chloride channels that are competitively antagonized by bicuculline, noncompetitively blocked by picrotoxin, and often allosterically modulated by barbiturates and benzodiazepines1–3. GABAB receptors regulate potassium and calcium channels through G-protein and intra-cellular second-messenger… CONTINUE READING
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