Novel GABA responses from rod- driven retinal horizontal cells

@article{Qian1993NovelGR,
  title={Novel GABA responses from rod- driven retinal horizontal cells},
  author={H. Qian and J. Dowling},
  journal={Nature},
  year={1993},
  volume={361},
  pages={162-164}
}
γ-AMINOBUTYRIC acid (GABA) is the main inhibitory neurotransmitter in the central nervous system. Two classes of GABA receptors (GABAA and GABAB) have been identified. GABAA receptors are ligandgated chloride channels that are competitively antagonized by bicuculline, noncompetitively blocked by picrotoxin, and often allosterically modulated by barbiturates and benzodiazepines1–3. GABAB receptors regulate potassium and calcium channels through G-protein and intra-cellular second-messenger… Expand
Differential pharmacology of GABAA and GABAC receptors on rat retinal bipolar cells.
TLDR
The results demonstrate that rod bipolar cells possess two populations of pharmacologically distinct GABA receptors, GABAA and novel-type GABAC receptors, which might subserve different physiological functions in controlling visual transduction in the retina. Expand
Chapter 9 GABAA Receptor-Activated Chloride Channels
Publisher Summary About 30% of neurons in the brain, particularly small interneurons, are thought to be gamma-aminobutyric acid (GABA)ergic (contain GAD) and most neurons responds to γ-AminobutyricExpand
Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina
  • H. Qian, J. Dowling
  • Chemistry, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
The GABA responses on H4 horizontal cells were resistant to several competitive GABAA receptor antagonists including bicuculline, hydrastine, and SR-95531, but they were very sensitive to picrotoxin. Expand
Bicuculline-resistant, Cl− dependent GABA response in the rat spinal dorsal horn
TLDR
It is reported here that bicuculline-resistant GABA responses mediated by chloride channels are also expressed in substantia gelatinosa (SG) neurons in the dorsal horn, which receive predominantly nociceptive inputs from periphery. Expand
Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology
TLDR
It is argued on functional grounds that the two GABA receptors coupled to Cl channels and to Ca channels are best regarded as members of the GABAA and GABAB families, respectively. Expand
GABA-gated Cl− Channels in the rat retina
TLDR
Electrophysiological characterization of GABA receptors expressed by amacrine and bipolar cells of the rat retina suggests that GABAA and GABAC receptors suggest that they have different inhibitory functions in theRat retina. Expand
GABAC receptors in the vertebrate retina
TLDR
Recent electrophysiological and molecular studies that have characterized the unique properties of GABAC receptors are reviewed and the roles that these receptors may play in visual information processing in the retina are described. Expand
Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina.
TLDR
The results with SR-95531 and bicuculline indicate that GABAA receptors mediate the inhibition responsible for directional selectivity, and suggests that feedforward GAB AA inhibition, as opposed to feedback at bipolar terminals, is responsible for the null inhibition underlying Directional selectivity. Expand
Ionotropic GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors.
TLDR
It is concluded that juvenile CA1 pyramidal cells express a fraction of ionotropic GABA receptors with mixed pharmacological properties of both, GABA(A) and GABA(C) receptors. Expand
Activation of GABA rho 1 receptors by glycine and beta-alanine.
TLDR
A new type of GABA receptor (GABA rho) is presented that, in contrast to GABAA and GABAB receptors, shows very little desensitization, is not blocked by bicuculline, and is not activated by baclofen. Expand
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