Novel GABA responses from rod- driven retinal horizontal cells

  title={Novel GABA responses from rod- driven retinal horizontal cells},
  author={Haohua Qian and John E. Dowling},
γ-AMINOBUTYRIC acid (GABA) is the main inhibitory neurotransmitter in the central nervous system. Two classes of GABA receptors (GABAA and GABAB) have been identified. GABAA receptors are ligandgated chloride channels that are competitively antagonized by bicuculline, noncompetitively blocked by picrotoxin, and often allosterically modulated by barbiturates and benzodiazepines1–3. GABAB receptors regulate potassium and calcium channels through G-protein and intra-cellular second-messenger… 

Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina

  • H. QianJ. Dowling
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
The GABA responses on H4 horizontal cells were resistant to several competitive GABAA receptor antagonists including bicuculline, hydrastine, and SR-95531, but they were very sensitive to picrotoxin.

Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology

It is argued on functional grounds that the two GABA receptors coupled to Cl channels and to Ca channels are best regarded as members of the GABAA and GABAB families, respectively.

GABA-gated Cl− Channels in the rat retina

GABAC receptors in the vertebrate retina

Recent electrophysiological and molecular studies that have characterized the unique properties of GABAC receptors are reviewed and the roles that these receptors may play in visual information processing in the retina are described.

Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina

The results with SR-95531 and bicuculline indicate that GABAA receptors mediate the inhibition responsible for directional selectivity, and suggests that feedforward GAB AA inhibition, as opposed to feedback at bipolar terminals, is responsible for the null inhibition underlying directionalSelectivity.

Activation of GABA rho 1 receptors by glycine and beta-alanine.

A new type of GABA receptor (GABA rho) is presented that, in contrast to GABAA and GABAB receptors, shows very little desensitization, is not blocked by bicuculline, and is not activated by baclofen.



Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.

Compared the electrical and pharmacological properties of GABA receptors expressed by poly(A)+ RNA isolated from mammalian brain and retina, these results suggest that mammalian retina contains RNAs encoding GABA receptors with distinct pharmacology.

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

It is reported that high-affinity saturable binding of 3H-baclof en and3H-G AB A to the GABAB site can be detected in fragments of crude synaptic membranes prepared from rat brain and that GABA and baclofen can compete for the same recognition site.

Characterization and ionic basis of GABA‐induced depolarizations recorded in vitro from cat primary afferent neurones.

Of the twelve structurally related compounds investigated, GABA was the most effective in its ability to produce a depolarization of the cell membrane.

GABAA receptor subtypes: from pharmacology to molecular biology

  • D. BurtG. Kamatchi
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
This review describes the little that is known about GABAA receptor subtypes and discusses approaches to establishing the subunit composition of subtypes, emphasizing possible molecular bases of receptor heterogeneity.

gamma-Aminobutyric acid-induced response in rat dissociated paratracheal ganglion cells.

The properties of GABAA receptors in the paratracheal ganglion cells are essentially similar to those reported in other preparations, indicating that PCG acts as a Cl- channel blocker.

gamma-Aminobutyric acid-induced response in acutely isolated nucleus solitarii neurons of the rat.

The gamma-aminobutyric acid (GABA)-induced macroscopic Cl- current (ICl) was investigated in acutely isolated nucleus tractus solitarii neurons by a conventional patch-clamp technique combined with a rapid drug application method, indicating that BIC and STR antagonized competitively and PCG noncompetitively.

Molecular biology of GABAA receptors

  • R. OlsenA. Tobin
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
Subpopulations of GABAA receptors with different cellular and regional locations show differential sensitivity to GABA, to modulators like steroids, to physiological regulation, to disease processes, and to pharmacological manipulation by drugs such as benzodiazepines.