Novel GABA responses from rod- driven retinal horizontal cells

@article{Qian1993NovelGR,
  title={Novel GABA responses from rod- driven retinal horizontal cells},
  author={Haohua Qian and John E. Dowling},
  journal={Nature},
  year={1993},
  volume={361},
  pages={162-164}
}
γ-AMINOBUTYRIC acid (GABA) is the main inhibitory neurotransmitter in the central nervous system. Two classes of GABA receptors (GABAA and GABAB) have been identified. GABAA receptors are ligandgated chloride channels that are competitively antagonized by bicuculline, noncompetitively blocked by picrotoxin, and often allosterically modulated by barbiturates and benzodiazepines1–3. GABAB receptors regulate potassium and calcium channels through G-protein and intra-cellular second-messenger… 

Pharmacology of novel GABA receptors found on rod horizontal cells of the white perch retina

  • H. QianJ. Dowling
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
The GABA responses on H4 horizontal cells were resistant to several competitive GABAA receptor antagonists including bicuculline, hydrastine, and SR-95531, but they were very sensitive to picrotoxin.

Presynaptic inhibition by GABA is mediated via two distinct GABA receptors with novel pharmacology

TLDR
It is argued on functional grounds that the two GABA receptors coupled to Cl channels and to Ca channels are best regarded as members of the GABAA and GABAB families, respectively.

GABA-gated Cl− Channels in the rat retina

GABAC receptors in the vertebrate retina

TLDR
Recent electrophysiological and molecular studies that have characterized the unique properties of GABAC receptors are reviewed and the roles that these receptors may play in visual information processing in the retina are described.

Contributions of GABAA receptors and GABAC receptors to acetylcholine release and directional selectivity in the rabbit retina

TLDR
The results with SR-95531 and bicuculline indicate that GABAA receptors mediate the inhibition responsible for directional selectivity, and suggests that feedforward GAB AA inhibition, as opposed to feedback at bipolar terminals, is responsible for the null inhibition underlying directionalSelectivity.

Activation of GABA rho 1 receptors by glycine and beta-alanine.

TLDR
A new type of GABA receptor (GABA rho) is presented that, in contrast to GABAA and GABAB receptors, shows very little desensitization, is not blocked by bicuculline, and is not activated by baclofen.
...

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