Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice

@inproceedings{Wamil2011NovelFD,
  title={Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice},
  author={Malgorzata Wamil and Jenny H. Battle and Sophie Turban and Tiina M. J. Kipari and David Seguret and Ricardo de Sousa Peixoto and Yvonne B. Nelson and Dominika Nowakowska and David A Ferenbach and Lynne E. Ramage and Karen E. Chapman and Jeremy H Hughes and Donald R. Dunbar and Jonathan R Seckl and Nicholas M Morton},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE The study objective was to determine the key early mechanisms underlying the beneficial redistribution, function, and inflammatory profile of adipose tissue in 11β-hydroxysteroid dehydrogenase type 1 knockout (11β-HSD1(-/-)) mice fed a high-fat (HF) diet. RESEARCH DESIGN AND METHODS By focusing on the earliest divergence in visceral adiposity… CONTINUE READING