Novel Dissolving Microneedles Preparation for Synergistic Melasma Therapy: Combined Effects of Tranexamic Acid and Licorice Extract.

@article{Xing2021NovelDM,
  title={Novel Dissolving Microneedles Preparation for Synergistic Melasma Therapy: Combined Effects of Tranexamic Acid and Licorice Extract.},
  author={Mengzhen Xing and Xue Wang and Lichun Zhao and Zequan Zhou and Han Liu and Baorui Wang and Aguo Cheng and Suohui Zhang and Yunhua Gao},
  journal={International journal of pharmaceutics},
  year={2021},
  pages={
          120406
        }
}
The aim of this study was to prepare dissolving microneedles (DMNs) patches containing tranexamic acid (TA) for the treatment of melasma. Polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) were preferred as matrix materials through the compatibility experiment. In the in vitro permeation study, the transdermal amount of TA was significantly promoted through dissolving microneedles with the cumulative release was 44.43 ± 6.55%. By comparison, the release of TA solution assisted with solid… Expand

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