Novel Delivery Systems for Nicotine Replacement Therapy as an Aid to Smoking Cessation and for Harm Reduction: Rationale, and Evidence for Advantages over Existing Systems

@article{Shahab2013NovelDS,
  title={Novel Delivery Systems for Nicotine Replacement Therapy as an Aid to Smoking Cessation and for Harm Reduction: Rationale, and Evidence for Advantages over Existing Systems},
  author={Lion Shahab and Leonie S. Brose and Robert J West},
  journal={CNS Drugs},
  year={2013},
  volume={27},
  pages={1007-1019}
}
Nicotine replacement therapy (NRT) has been used in the treatment of tobacco dependence for over three decades. Whilst the choice of NRT was limited early on, in the last ten years there has been substantial increase in the number of nicotine delivery devices that have become available. This article briefly summarises existing forms of NRT, evidence of their efficacy and use, and reviews the rationale for the development of novel products delivering nicotine via buccal, transdermal or pulmonary… 
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34 Citations
Background Citations
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34 Citations

Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System
TLDR
P3L is an innovative nicotine delivery product that will be acceptable to adult smokers as an alternative to cigarettes and shows potential over existing nicotine delivery systems by delivering nicotine with kinetics close to published data on conventional cigarettes and without exogenous carrier substances.
Pharmacological therapies in smoking cessation: an evidence-based update
TLDR
Recent updates to the literature regarding nicotine replacement, bupropion, and varenicline are reviewed; re-emerging therapies such as cytisine are reviewed, as well as the novel concept of vaccination.
New Pharmacological Agents to Aid Smoking Cessation and Tobacco Harm Reduction: What Has Been Investigated, and What Is in the Pipeline?
TLDR
This paper compares the first-line smoking cessation medications with 24 alternative products, and cytisine looks most promising in having established efficacy and safety with low cost.
Electronic cigarettes are at least as effective as nicotine patches for smoking cessation
TLDR
E-cigarettes have been shown to reduce craving and withdrawal symptoms in abstinent smokers and, as nicotine is delivered without tobacco combustion, are thought to be substantially safer than cigarettes.
Current and Emerging Pharmacotherapies for Cessation of Tobacco Smoking
TLDR
This article reviewed existing and emerging smoking cessation pharmacotherapies, with a special emphasis on the most promising agents that are currently being investigated, including NRT, bupropion, and varenicline.
Review: Pharmacotherapy for smoking cessation
TLDR
The use of NRT (nicotine patch + nicotine gum/lozenge/inhaler/spray), bupropion (with NRT), or varenicline is strongly recommended for smoking cessation, unlessthey are contraindicated.
Deregulation of Nicotine Replacement Therapy Products in Finland : Reasons for Pharmaceutical Policy Changes and Reflections on Smoking Cessation Practices
TLDR
The analysis revealed that two of the most important motives for the deregulation, poor NRT availability and NRT’s effectiveness in SC, were largely based on assumptions instead of actual scientific evidence.
Prevalence of NRT Use and Associated Nicotine Intake in Smokers, Recent Ex-Smokers and Longer-Term Ex-Smokers
TLDR
Conurrent use of nicotine replacement therapy while smoking is relatively uncommon and is not associated with higher levels of nicotine intake, but among ex-smokers, NRT use is common in the short but not longer-term and among longer- term users is associated with lower nicotine intake than in smokers.
Prevalence and impact of long-term use of nicotine replacement therapy in UK stop-smoking services: findings from the ELONS study. Nicotine and
TLDR
This study shows that in the context of SSS, clients rarely use products for up to a year and that NRT use does not affect users’ stress response, and appears to be a safe and effective way to reduce exposure to combustible nicotine.
Time controlled pulsatile transdermal delivery of nicotine: A phase I feasibility trial in male smokers.
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