Novel Delivery Systems for Nicotine Replacement Therapy as an Aid to Smoking Cessation and for Harm Reduction: Rationale, and Evidence for Advantages over Existing Systems
@article{Shahab2013NovelDS, title={Novel Delivery Systems for Nicotine Replacement Therapy as an Aid to Smoking Cessation and for Harm Reduction: Rationale, and Evidence for Advantages over Existing Systems}, author={Lion Shahab and Leonie S. Brose and Robert J West}, journal={CNS Drugs}, year={2013}, volume={27}, pages={1007-1019} }
Nicotine replacement therapy (NRT) has been used in the treatment of tobacco dependence for over three decades. Whilst the choice of NRT was limited early on, in the last ten years there has been substantial increase in the number of nicotine delivery devices that have become available. This article briefly summarises existing forms of NRT, evidence of their efficacy and use, and reviews the rationale for the development of novel products delivering nicotine via buccal, transdermal or pulmonary…
34 Citations
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The use of NRT (nicotine patch + nicotine gum/lozenge/inhaler/spray), bupropion (with NRT), or varenicline is strongly recommended for smoking cessation, unlessthey are contraindicated.
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Conurrent use of nicotine replacement therapy while smoking is relatively uncommon and is not associated with higher levels of nicotine intake, but among ex-smokers, NRT use is common in the short but not longer-term and among longer- term users is associated with lower nicotine intake than in smokers.
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This study shows that in the context of SSS, clients rarely use products for up to a year and that NRT use does not affect users’ stress response, and appears to be a safe and effective way to reduce exposure to combustible nicotine.
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This study shows that in the context of SSS, clients rarely use products for up to a year and that NRT use does not affect users’ stress response, and long-term NRT appears to be a safe and effective way to reduce exposure to combustible nicotine.
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