Novel Decaturin Alkaloids from the Marine-Derived Fungus Penicillium Oxalicum

@article{Wang2013NovelDA,
  title={Novel Decaturin Alkaloids from the Marine-Derived Fungus Penicillium Oxalicum},
  author={Pei-le Wang and Dan-yi Li and Lei-rui Xie and Xin Wu and Huiming Hua and Zhanlin Li},
  journal={Natural Product Communications},
  year={2013},
  volume={8}
}
From the mycelia of Penicillium oxalicum two new compounds, decaturins E (1) and F (2), have been isolated, along with four known analogues, decaturin A (3), decaturin C (4), decaturin D (5), and oxalicine B (6). The structures were determined by HR-ESI-MS and 1D and 2D NMR analysis. 

Figures and Tables from this paper

New Verrucosidin Derivatives from the Marine-Derived Fungus Penicillium sp. XL-01
Two new verrucosidin derivatives, named nordeoxyverrucosidin (1) and norverrucosidinol acetate (2), along with three known analogues (3–5) were isolated from the marine-derived fungus Penicillium sp.
Phenylhydrazone and Quinazoline Derivatives from the Cold-Seep-Derived Fungus Penicillium oxalicum
TLDR
Three new phenylhydrazones, penxahydrazones A–C, and two new quinazolines, penoxazolones A and B, with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep, showing inhibition of several marine phytoplankton species and marine-derived bacteria.
A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290
Abstract Ten secondary metabolites (1–10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were
Marine natural products sourced from marine-derived Penicillium fungi
TLDR
This review highlights the 390 new MNPs from marine-derived Penicillium fungi during 1991 to 2014, categorized based on the environment sources of the fungal hosts and their bioactivities are summarized.
Antimicrobial Meroterpenoids and Erythritol Derivatives Isolated from the Marine-Algal-Derived Endophytic Fungus Penicillium chrysogenum XNM-12
TLDR
One new meroterpenoid-type alkaloid, oxalicine C (1), and two new erythritol derivatives, penicierythritols A (6) and B (7) are the first reported from the Penicillium species and the antimicrobial activities of compounds 1–7 were evaluated.
Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01965f
The biosynthetic pathway of a diterpenic meroterpenoid was elucidated by combination of genome mining, gene targeting, and natural product chemistry.
Taxonomic revision of the biotechnologically important species Penicillium oxalicum with the description of two new species from acidic and saline soils
TLDR
This study revised a set of Penicillium isolates from various sources including P. oxalicum-like strains obtained from acidic and saline soils in the Soos Nature Reserve (Czech Republic) and identified two phylogenetic sister species that can be distinguished from P.Oxalicum based on molecular data, morphological characters, and extrolite profiles.
Comprehensive Overview on the Chemistry and Biological Activities of Selected Alkaloid Producing Marine-Derived Fungi as a Valuable Reservoir of Drug Entities
TLDR
Most of the reported bioactive alkaloids showed considerable biological activities mainly cytotoxic followed by antibacterial, antifungal, antiviral, antioxidant; however, a few showed anti-inflammatory and antifouling activities and required further investigations for additional biological activities.
The chemistry and biology of fungal meroterpenoids (2009-2019).
TLDR
This review provides a systematic overview of the isolation, chemical structural features, biological activities, and fungal biodiversity of 1585 novel meroterpenoids from 79 genera terrestrial and marine-derived fungi including macrofungi, Basidiomycetes, in 441 research papers in 2009-2019.
...
...

References

SHOWING 1-4 OF 4 REFERENCES
Antiinsectan decaturin and oxalicine analogues from Penicillium thiersii.
TLDR
Three new oxalicine and decaturin analogues have been isolated from organic extracts of Penicillium thiersii, along with the known compounds oxAlicines A and B, which exhibit potent antiinsectan activity against the fall armyworm.
First Synthesis and Absolute Configuration of Decaturin D
The first synthesis of (+)-decaturin D (1), an antiinsectant diterpenoid isolated from Penicillium thiersii, was accomplished by employing our original spiro-cyclization reaction as the key step. The
Secondary metabolites of fungi from marine habitats.
TLDR
An overview of new natural products from marine-derived fungi and their biological activities, focusing on the period from 2006 until mid-2010, with a considerable number of which display promising biological and pharmacological properties.