Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse.

@article{Hewitt2014NovelDM,
  title={Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse.},
  author={Sylvia C Hewitt and LePing Li and Sara A. Grimm and Wipawee Winuthayanon and Katherine J. Hamilton and Brianna Pockette and Cory A. Rubel and Lars C Pedersen and David Fargo and Rainer B. Lanz and Francesco J. Demayo and G. Sch{\"u}tz and KennethS. Korach},
  journal={Molecular endocrinology},
  year={2014},
  volume={28 6},
  pages={
          899-911
        }
}
Estrogen receptor α (ERα) interacts with DNA directly or indirectly via other transcription factors, referred to as "tethering." Evidence for tethering is based on in vitro studies and a widely used "KIKO" mouse model containing mutations that prevent direct estrogen response element DNA- binding. KIKO mice are infertile, due in part to the inability of estradiol (E2) to induce uterine epithelial proliferation. To elucidate the molecular events that prevent KIKO uterine growth, regulation of… CONTINUE READING
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