Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.

@article{Langevin2014NovelDM,
  title={Novel DNA methylation targets in oral rinse samples predict survival of patients with oral squamous cell carcinoma.},
  author={Scott M. Langevin and Rondi A. Butler and Melissa Nicole Eliot and Michael Pawlita and Jennifer Z J Maccani and Michael D Mcclean and Karl T. Kelsey},
  journal={Oral oncology},
  year={2014},
  volume={50 11},
  pages={
          1072-80
        }
}
OBJECTIVES The objective of this study was to identify novel survival-associated biomarkers in oral rinse samples collected from patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS We screened for putative survival-associated markers using publicly available methylation array data from 88 OSCC tumors. Cox models were then fit to methylation array data restricted to these putative loci in oral rinse samples of 82 OSCC patients from greater Boston. Pyrosequencing assays… CONTINUE READING
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