Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus.

@article{Pujol2002NovelDH,
  title={Novel DL-galactan hybrids from the red seaweed Gymnogongrus torulosus are potent inhibitors of herpes simplex virus and dengue virus.},
  author={Carlos Alberto Pujol and Jos{\'e} Manuel Estevez and Marla J Carlucci and Marina Ciancia and Alberto Sa{\'u}l Cerezo and Elsa B Damonte},
  journal={Antiviral chemistry & chemotherapy},
  year={2002},
  volume={13 2},
  pages={83-9}
}
A novel series of DL-galactan hybrids extracted from the red seaweed Gymnogongrus torulosus, was evaluated for its in vitro antiviral properties against herpes simplex virus type 2 (HSV-2) and dengue virus 2 (DEN-2). These compounds were very active against both viruses with inhibitory concentration 50% (IC50) values in the range 0.6-16 microg/ml for HSV-2 and 0.19-1.7 microg/ml for DEN-2, respectively, as determined in a virus plaque reduction assay in Vero cells. The DL-galactans lacked of… CONTINUE READING