Novel D-ring analog of epigallocatechin-3-gallate inhibits tumor growth and VEGF expression in breast carcinoma cells.

@article{Waleh2005NovelDA,
  title={Novel D-ring analog of epigallocatechin-3-gallate inhibits tumor growth and VEGF expression in breast carcinoma cells.},
  author={Nahid S. Waleh and Wan-ru Chao and Ahlem Bensari and Nurulain T. Zaveri},
  journal={Anticancer research},
  year={2005},
  volume={25 1A},
  pages={397-402}
}
The cancer chemopreventive activity of green tea and its major polyphenolic constituent, epigallocatechin-3-gallate (EGCG) have been attributed to its antioxidant, antiproliferative and antiangiogenic effects. Several new molecular targets for EGCG's anticarcinogenic activity have been proposed in the recent literature. However, the understanding of the molecular mechanisms of EGCG's activity in vivo have been confounded by its low oral bioavailability and low plasma levels. Studies of EGCG… CONTINUE READING