Novel Cs-Based Upconversion Nanoparticles as Dual-Modal CT and UCL Imaging Agents for Chemo-Photothermal Synergistic Therapy
@article{Liu2016NovelCU, title={Novel Cs-Based Upconversion Nanoparticles as Dual-Modal CT and UCL Imaging Agents for Chemo-Photothermal Synergistic Therapy}, author={Yuxin Liu and Luoyuan Li and Quanwei Guo and Lu Wang and Dongdong Liu and Ziwei Wei and Jing Zhou}, journal={Theranostics}, year={2016}, volume={6}, pages={1491 - 1505} }
Lanthanide-based contrast agents have attracted increasing attention for their unique properties and potential applications in cancer theranostics. To date, many of these agents have been studied extensively in cells and small animal models. However, performance of these theranostic nanoparticles requires further improvement. In this study, a novel CsLu2F7:Yb,Er,Tm-based visual therapeutic platform was developed for imaging-guided synergistic cancer therapy. Due to the presence of the heavy…
50 Citations
Designing of UCNPs@Bi@SiO2 Hybrid Theranostic Nanoplatforms for Simultaneous Multimodal Imaging and Photothermal Therapy.
- Biology, EngineeringACS applied materials & interfaces
- 2019
The effective UCL/CT imaging and PTT performances were emphasized by a series of in vivo experiments, which suggest that the integrated nanoplatform with imaging and therapy functions shows great promise in the biomedical field.
Stimuli-responsive nanotheranostics based on lanthanide-doped upconversion nanoparticles for cancer imaging and therapy: current advances and future challenges
- Biology, Materials ScienceNano Today
- 2019
NIR Laser Responsive Nanoparticles for Ovarian Cancer Targeted Combination Therapy with Dual-Modal Imaging Guidance
- Biology, Materials ScienceInternational journal of nanomedicine
- 2021
These multifunctional theranostic FBPD NPs were constructed for highly efficient PTT/chemotherapy combined therapy with dual CT/PA imaging guidance/monitoring and demonstrated their outstanding imaging capability for both PA and CT imaging both in vitro and in vivo.
New advances on the marrying of UCNPs and photothermal agents for imaging-guided diagnosis and the therapy of tumors.
- BiologyJournal of materials chemistry. B
- 2017
New advances in the design and the therapeutic applications of multifunctional UCNPs-NIR absorber nanoplatforms and the future challenges and prospects in this field are addressed.
Ultra-small pH-responsive Nd-doped NaDyF4 Nanoagents for Enhanced Cancer Theranostic by in situ Aggregation
- Chemistry, BiologyTheranostics
- 2017
The optimized nanoagents have potential applications in medical and also provide a novel strategy for future study of cancer theranostic enhancement.
A chemophotothermal and targeting multifunctional nanoprobe with a tumor-diagnosing ability
- Biology, ChemistryNano Research
- 2018
A novel nanoprobe consisting of hyaluronic-acid–modified Gold Nanorods@mSiO2@Mn @DOX (GNR@MMH@DOX) nanoparticles, which realize multifunctional integration of therapeutics and imaging is reported, demonstrating promising composition for CT/MR imaging and photothermal therapy of tumors.
A Smart Responsive Dual Aptamers-Targeted Bubble-Generating Nanosystem for Cancer Triplex Therapy and Ultrasound Imaging.
- BiologySmall
- 2017
The results indicate that this drug delivery system is a promising theranostic agent involving light-thermal response at tumor sites, dual ligand targeted triplex therapy, and USI.
Light-activatable dual prodrug polymer nanoparticle for precise synergistic chemotherapy guided by drug-mediated computed tomography imaging.
- Biology, Materials ScienceActa biomaterialia
- 2019
Polymer hybrid magnetic nanocapsules encapsulating IR820 and PTX for external magnetic field-guided tumor targeting and multifunctional theranostics.
- Biology, Materials ScienceNanoscale
- 2017
The synergistic therapeutic effects of NC-SPIOs-IR820-PTX with extra-magnetic field-induced tumor targeting ability have enhanced the co-therapy of photo-chemotherapy, resulting in significant tumor inhibition effects.
Light-Activatable Precise Synergistic Chemotherapy Through a Dual Prodrug Polymer Guided by Drug-Mediated Computed Tomography Imaging
- Biology, Materials ScienceSSRN Electronic Journal
- 2019
Guided by Pt DMCT imaging, DPP NP showed an excellent light-activatable antitumor efficacy and low toxicity with 75% fully cured tumors, and could be potential for precise theranostic nanomedicine.
References
SHOWING 1-10 OF 51 REFERENCES
Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes.
- Biology, ChemistryBiomaterials
- 2014
Folic acid-conjugated LaF3:Yb,Tm@SiO2 nanoprobes for targeting dual-modality imaging of upconversion luminescence and X-ray computed tomography.
- Biology, ChemistryThe journal of physical chemistry. B
- 2012
The results suggest that the as-prepared nanoprobe is a good candidate with excellent imaging and targeting ability for targeting dual-modality imaging of UCL and CT.
Single Ho3+‐Doped Upconversion Nanoparticles for High‐Performance T2‐Weighted Brain Tumor Diagnosis and MR/UCL/CT Multimodal Imaging
- Biology
- 2014
The first example of T2‐weighted MR imaging of Ho3+‐doped upconversion nanoparticles (UCNPs) is presented, which, very attractively, could also be simultaneously used for upconverting luminesence (UCL) and CT imaging, thus enabling high performance multi‐modal MRI/UCL/CT imagings in single UCNPs.
Dual modal in vivo imaging using upconversion luminescence and enhanced computed tomography properties.
- Materials Science, BiologyNanoscale
- 2011
These nanoprobes with dual modal in vivo imaging of UCL and CT can serve as a promising platform for clinical diagnosis or biomedical studies and no background autofluorescence signal is found in in vivo UCL images.
Gd3+ complex-modified NaLuF4-based upconversion nanophosphors for trimodality imaging of NIR-to-NIR upconversion luminescence, X-Ray computed tomography and magnetic resonance.
- Biology, ChemistryBiomaterials
- 2012
IR-780 dye loaded tumor targeting theranostic nanoparticles for NIR imaging and photothermal therapy.
- Biology, ChemistryBiomaterials
- 2013
Nano-assemblies of J-aggregates based on a NIR dye as a multifunctional drug carrier for combination cancer therapy.
- Biology, ChemistryBiomaterials
- 2015
Gold Nanorods Conjugated with Doxorubicin and cRGD for Combined Anticancer Drug Delivery and PET Imaging
- Biology, ChemistryTheranostics
- 2012
This multifunctional GNR-based nanoplatform can potentially be optimized for combined cancer therapies and multimodality imaging (PET, optical, X-ray computed tomography (CT), etc.
Tungsten Oxide Nanorods: An Efficient Nanoplatform for Tumor CT Imaging and Photothermal Therapy
- Materials Science, BiologyScientific reports
- 2014
The formed PEGylated WO2.9 NRs are able to inhibit the growth of the model cancer cells in vitro and the corresponding tumor models in vivo, and enable effective CT imaging of the tumor model in vivo.
TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance.
- Biology, Materials ScienceBiomaterials
- 2015