Novel Common Integration Sites Targeted by Mouse Mammary Tumor Virus Insertion in Mammary Tumors Have Oncogenic Activity

Abstract

Non-acute transforming retroviruses like mouse mammary tumor virus (MMTV) cause cancer, at least in part, through integration near cellular genes involved in growth control, thereby de-regulating their expression. It is well-established that MMTV commonly integrates near and activates expression of members of the Wnt and Fgf pathways in mammary tumors… (More)
DOI: 10.1371/journal.pone.0027425

Topics

10 Figures and Tables

Cite this paper

@inproceedings{Kim2011NovelCI, title={Novel Common Integration Sites Targeted by Mouse Mammary Tumor Virus Insertion in Mammary Tumors Have Oncogenic Activity}, author={Hyoung Ho Kim and A. Pieter J. van den Heuvel and John W Schmidt and Susan R Ross}, booktitle={PloS one}, year={2011} }