Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety.

@article{Chaudhary2016NovelCA,
  title={Novel Combretastatin-2-aminoimidazole Analogues as Potent Tubulin Assembly Inhibitors: Exploration of Unique Pharmacophoric Impact of Bridging Skeleton and Aryl Moiety.},
  author={Vikas Chaudhary and Jubina B. Venghateri and Hemendra Pal Singh Dhaked and Anil S Bhoyar and Sankar K Guchhait and Dulal Panda},
  journal={Journal of medicinal chemistry},
  year={2016},
  volume={59 7},
  pages={3439-51}
}
Combretastatin A-4 (CA-4) in phosphate and serine pro-drug forms is under phase II clinical trials. With our interest of discovering CA-4 inspired new chemical entities, a novel series of 4,5-diaryl-2-aminoimidazole analogues of the compound was designed and synthesized by an efficient and diversity feasible route involving atom economical arene C-H bond arylation. Interestingly, four compounds showed potent cell-based antiproliferative activities in nanomolar concentrations. Among the… CONTINUE READING
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